Matthew Wiens, M.A.

Senior Scientist II

Matthew joined Metrum in 2019 as a Research Scientist. He holds an M.A. in Statistics from Boston University. Prior to Metrum, he worked for a variety of startup technology companies where he applied Bayesian methodologies in predictive models based on remote sensing data. His ongoing interests include communicating and leveraging uncertainty from a Bayesian perspective in scalable modeling and simulation projects.

Recent publications by this scientist

Consistency between ML and Classical Approaches for Covariate Identification

April 1, 2024

Presented at ASCPT Annual Meeting 2024. Discover the synergy between Machine Learning and classical approaches in covariate identification. Our scientist, Matthew Wiens, explored this vital topic at the pre-conference session ‘Empowering Clinical Pharmacologists and Translational Scientists Using Artificial Intelligence: Unlocking Potential with Cutting-Edge Use Cases.’

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Population exposure–response analysis supports efficacy outcomes of garadacimab in patients with hereditary angioedema

June 26, 2024

Presented at ASCPT Annual Meeting 2024. Garadacimab (anti-activated factor XII monoclonal antibody) demonstrated efficacy for the prevention of hereditary angioedema (HAE) attacks with a favorable safety profile in Phase 2, pivotal Phase 3 (VANGUARD), and Phase 3 open-label extension studies. In this exposure-response (ER) analysis, the efficacy of garadacimab and effect of covariates on attack rate (number of attacks/month) were assessed to support garadacimab dosing in patients with HAE.

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Bayesian estimation in NONMEM

December 11, 2023

In this tutorial, the principles of Bayesian model development, assessment and prior selection are outlined. An example pharmacokinetic model is used to demonstrate the implementation of Bayesian modeling using the nonlinear mixed-effects modeling software NONMEM.

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