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October 2018

Bayesian analysis of categorical, count and time-to-event data with Stan, rstanarm and Torsten

October 7 @ 8:00 am - 5:00 pm

We will provide a guided hands-on experience in the use of Stan (http://mc-stan.org/), rstan (http://mc-stan.org/interfaces/rstan.html), rstanarm (http://mc-stan.org/users/interfaces/rstanarm.html) and Torsten (https://github.com/metrumresearchgroup/example-models) for Bayesian analysis of categorical, count and time-to-event data. Stan is a flexible open-source software tool for Bayesian data analysis using Hamiltonian Monte Carlo (HMC) simulation---a type of MCMC simulation. Torsten is a Stan extension containing a library of functions to simplify implementation of PKPD models. This workshop builds on the foundations presented in our previous introductory Stan workshops (http://metrumrg.com/events/2016/10/23/bayesianpkpd.html).…

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Introduction to PBPK modeling in R with mrgsolve

October 11 @ 1:00 pm - October 12 @ 5:00 pm

This hands-on workshop will provide participants with a technical foundation for physiologically-based pharmacokinetic (PBPK) model development in R using mrgsolve, a free, open-source modeling and simulation platform for ODE-based model development in R (https://mrgsolve.github.io).  The workshop gets started with an introduction to simulation with mrgsolve.  We'll cover the essentials of a tidy simulation workflow in R. Then we'll jump into PBPK modeling with mrgsolve.  After a brief introduction to principles of PBPK, we'll work through case studies using PBPK modeling.…

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