Katherine Kay, Ph.D.

Research Scientist & Reporting Specialist I

Katherine joined Metrum in August 2018 as a Research Scientist. Katherine completed her Ph.D at Liverpool School of Tropical Medicine (LSTM), University of Liverpool, UK. Her dissertation work involved developing and implementing pharmacokinetic-pharmacodynamic (PK-PD) models of antimalarial drug action. In collaboration with the Swiss Tropical and Public Health Institute (Swiss TPH), Katherine translated these models of drug action into their open-source simulation platform of malaria epidemiology and control, “OpenMalaria”. Katherine continued to collaborate with Swiss TPH as a post-doctoral research associate based at LSTM. Her work extended antimalarial PK-PD model methodology to investigate drug resistance and to optimize dosing regimens in malaria treatment, and contributed to ongoing insecticide resistance modeling.

In 2015, Katherine moved to the University at Buffalo, NY, USA, where she developed a physiologically-based pharmacokinetic (PBPK) model to characterize the physiological structure of the vaginal space and the absorption/distribution of vaginally administered drugs. The model specifically focused on the administration of antiretroviral compounds delivered via either a ring or film formulation and aimed at optimizing the probability of success of vaginally administered antiretroviral drugs.

Recent publications by this scientist

Development and validation of open-source pharmacometrics software using an iterative software development life cycle methodology: the pmtables R package for submission-ready table generation

September 13, 2021

Kyle T. Baron, Devin Pastoor, Anna Nevison, Katherine Kay, Marc R. Gastonguay. Poster presented at Population Approach Group Europe Annual Meeting; 2-3 and 6-7 September 2021.  Poster III-02.

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Incorporating genetic selection into individual‐based models of malaria and other infectious diseases

November 30, 2020

Hastings, IMHardy, DKay, KSharma, REvol Appl2020132723– 2739https://doi.org/10.1111/eva.13077

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Modeling and simulation of lumefantrine pharmacokinetics in HIV-infected and HIV-uninfected children with malaria and the role of lumefantrine exposure as a potential driver of drug resistance

November 16, 2020

Kay K, Goodwin J, Mwebaza N, Ruiz A, Ehrlich H, Ou J, Freeman T, Wade M, Huang L, Wang K, Li F, Aweeka FT, Riggs M, Kajubi R, Parikh S.  Presented at the annual meeting of the American Society of Tropical Medicine and Hygiene, October 16-18, 2020.

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