William Knebel, Pharm.D., Ph.D.


Bill joined MetrumRG in 2004, where he was appointed President of Strategic Modeling & Simulation in 2016 after serving most recently as Principal Scientist II and Group Leader of the Pharmacology Modeling & Simulation Team. Bill has worked extensively in applying mathematical modeling and simulation techniques to optimize drug development across both academic and industrial settings. In his 12 years at MetrumRG, Bill has taken a leadership role in strengthening our team’s capabilities and has been a champion of applying high-performance cloud computing environments to facilitate problem solving in drug development.

Recent publications by this scientist

Population Pharmacokinetic Analysis of Pexidartinib in Healthy Subjects and Patients with Tenosynovial Giant Cell Tumor (TGCT) or Other Solid Tumors

November 18, 2019

Ophelia Yin, Jia Kang, William Knebel, Hamim Zahir, Michiel van de Sande, William D. Tap, Hans Gelderblom, Silvia Stacchiotti, Jon Greenberg, Dale Shuster, Andrew J. Wagner

Poster presented at 2019 American Conference on Pharmacometrics (ACoP10) in Orlando, FL. 21 October 2019.

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Population PK modeling and target attainment simulations to support dosing of ceftaroline fosamil in pediatric patients with acute bacterial skin and skin structure infections and community-acquired bacterial pneumonia

March 1, 2017

Riccobene TA, Khariton T, Knebel W, Das S, Li J, Jandourek A, Carrothers TJ, Bradley JS.  The Journal of Clinical Pharmacology, March 2017; 57: 345–355. doi: 10.1002/jcph.809

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Penetration of ceftaroline into the epithelial lining fluid of healthy adult subjects

September 23, 2016

Riccobene TA, Pushkin R, Jandourek A, Knebel W, Khariton T.  Antimicrob Agents Chemother. 2016 Sep 23;60(10):5849-57.

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