Rena J. Eudy-Byrne, Ph.D.

Research Scientist

Rena joined Metrum in November 2015 after completing her Ph.D. in Biomedical Engineering at the University of Connecticut. Her dissertation work included extending a systems pharmacology model of bone and osteoporosis to be relevant for the development new therapies. Part of this work included linking simulated changes in bone mineral density to a hazard model of fracture in a Bayesian framework in order to predict the probability of fracture in osteoporosis patients. Analysis tools for establishing a priori identifiability of target-mediated drug disposition and other indirect response-type models were also part of this larger work. Rena brings 5 years of industry experience to the team, including work in preclinical development in metabolic systems and neuroscience and using systems pharmacology models to inform clinical decisions.

Recent publications by this scientist

A model of fracture risk used to examine the link between bone mineral density and the impact of different therapeutic mechanisms on fracture outcomes in patients with osteoporosis

November 3, 2017

Eudy-Byrne RJ, Gillespie W, Riggs MM. Gastonguay MR. J Pharmacokinet Pharmacodyn (2017).  First online 28 Oct 2017. https://doi.org/10.1007/s10928-017-9551-z

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A mathematical model to quantify links between bone mineral density, patient factors and therapeutic interventions on fracture risk in patients with osteoporosis

September 2, 2016

Eudy-Byrne RJ, Gillespie WR, Riggs MM, Gastonguay MR.  Poster presented at: American Society for Bone and Mineral Research Annual Meeting; September 2016.

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Comparing the performance of four open-source methods for multiple parameter estimation in a systems pharmacology model

June 1, 2016

Eudy RJ, Riggs MM, Baron K.  Presented at the Sanofi–MSISB Mount Sinai Systems Pharmacology Symposium, June 2016.

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