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June 2020

A Gentle Introduction to Optimal Design for Pharmacometric Models

June 8, 2020 @ 12:00 pm - 1:00 pm
Online,

Throw open the basement hatch (virtually) and join Metrum Research Group for an open-learning approach to open-science.

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August 2020

StanCon 2020

August 13, 2020

Join MetrumRG scientists at StanCon 2020, which will be presented virtually. Information and registration can be found here: https://mc-stan.org/events/stancon2020/

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September 2020

Analysis & Reporting of QTc Prolongation Potential of New Drugs Using R Tools, Expectations & General Guidance for Regulatory Submissions

September 19, 2020 @ 8:00 am - 11:30 am

Ana Ruiz-Garcia, PharmD, PhD, joins Dhananjay D. Marathe, PhD, to co-chair a pre-meeting workshop for the virtual American College of Clinical Pharmacology's annual meeting. Attendees of the workshop will be able to become familiar with the ECG-pharmacokinetic analysis using R, create a report using R Markdown, Gan understanding about the sample size and exposure margin requirements for TQT substitution request based on studies without a positive control and bring a deeper understanding of some of the common challenges and potential…

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October 2020

A PK & PBPK Modeling Workflow in R: Simulation, Optimization & Visualization

October 9, 2020 @ 11:00 am - 3:00 pm
R/Pharma Conference, (Virtual) + Google Map

After a brief introduction to mrgsolve (https://mrgsolve.github.io), we will discuss concepts and applications for using the package in R to simulate from pharmacokinetic (PK) and physiologically-based PK (PBPK) models, estimate parameters given a model and data, and visualize simulation results with a Shiny app. We will establish a basic framework for running optimization in R and work hands-on examples using different optimizers, including local and global search algorithms. Building on this framework, we will also illustrate related workflows including global…

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November 2020

ACoP11 – American Conference on Pharmacometrics

November 9, 2020 @ 8:00 am - November 13, 2020 @ 5:00 pm

Join MetrumRG scientists at the eleventh American Conference on Pharmacometrics (ACoP11)--the annual scientific meeting of the International Society of Pharmacometrics (ISoP).  The conference is virtual this year and runs November 9 - 13. ACoP's theme this year is “Scaling New Heights,” aligning with ISoP's 5-year strategic plan to actively champion the expanding role of pharmacometrics in protecting and improving human health. Presentations Wed, Nov 11, Second Session: Marc Gastonguay to present "Markov Models at the Intersection of Pharmacometrics and Health…

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March 2021

MetrumRG at ASCPT

March 8, 2021 - March 12, 2021

Join MetrumRG at the American Society for Clinical Pharmacology & Therapeutics (ASCPT) Annual Meeting. The conference is virtual this year and runs March 8-12 and March 15-17. If you'd like to connect with us during the meeting, reach out here and suggest a time to meet.  We would be glad to discuss clin pharm topics or share our capabilities with you! MetrumRG Contributors at ASCPT Thur. Mar 11, 10:15 AM ET  -  Marc Gastonguay, Ph.D. to deliver a lecture for…

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MetrumRG at ASCPT

March 15, 2021 - March 17, 2021

Join MetrumRG at the American Society for Clinical Pharmacology & Therapeutics (ASCPT) Annual Meeting. The conference is virtual this year and runs March 8-12 and March 15-17. If you'd like to connect with us during the meeting, reach out here and suggest a time to meet.  We would be glad to discuss clin pharm topics or share our capabilities with you! MetrumRG Contributors at ASCPT Thur. Mar 11, 10:15 AM ET  -  Marc Gastonguay, Ph.D. to deliver a lecture for…

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May 2021

Interactive Simulation to Integrate Pharmacometrics and Health Economics

May 4, 2021 @ 1:00 pm - 2:00 pm
Online (Zoom),

Join us for a free online workshop hosted by ASCPT!  This workshop expands on a topic covered in this year's ASCPT meeting, Opportunities at the Intersection of Pharmacometrics and Health Economics for Insightful Drug Development Decision Making.  In this one-hour webinar, we'll review an example of a web-based interactive simulation app that explores the expected relationships between pharmacometric characteristics of hypothetical new treatments and the cost effectiveness of the treatment in the indication of atopic dermatitis. Considerations for pharmacometric and…

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October 2022

A showcase of open-source tools for scalable, reproducible PMx workflows

October 30 @ 12:00 pm - 5:00 pm
Gaylord Rockies Resort & Convention Center, 6700 N Gaylord Rockies Blvd
Aurora, Colorado 80019
+ Google Map

Cost: Industry: $300 / Academia+Government: $200 / Student: $100 Join us for a half-day pre-meeting workshop at ACoP13! Instructors Kyle Baron, PharmD, PhD Sam Callisto, PhD Seth Green, MS Matthew Riggs, PhD Learning Objectives Identify the available open-source R packages developed by MetrumRG to support traceable, reproducible, and scalable pharmacometric analyses Explore a reproducible pharmacometric analysis workflow Topic Outline Introduction to MetrumRG’s open-source R package ecosystem Metrum Package Network (MPN) / pkgr: curated, reproducible R package environment  bbi/bbr: a user-friendly…

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November 2022

Exposure-response modeling for binary and time-to-event data using R and Stan

November 3 @ 8:00 am - November 4 @ 4:00 pm
Gaylord Rockies Resort & Convention Center, 6700 N Gaylord Rockies Blvd
Aurora, Colorado 80019
+ Google Map

Cost: Industry: $1,200 / Academia+Government: $800 / Student: $400 Join us for a 2-day workshop following ACoP13! Instructors Jim Rogers, PhD Andrew Tredennick, PhD Matthew Weins, MA Ramon Garcia, PhD Learning Objectives Describe confounded exposure-response Analyze binary data (exploratory analysis and modeling using R and Stan) Analyze time-to-event data (exploratory analysis, semi-parametric and parametric modeling using R and Stan) Interpret TTE models with continuously time-varying hazard Topic Outline Day 1 Study designs and confounded exposure-response General theory / background Binary data…

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