A free ASCPT post-conference workshop and reception sponsored by Metrum Research Group Date: Saturday, March 21, 2020 Time: Workshop - 2:00-4:00PM (CST), Reception - 4:00-5:00PM (CST) Instructors: Marc R. Gastonguay & Matthew M. Riggs Space is limited. No more than 4 attendees from a given institution or company, please. Workshop Overview Bayesian data analysis methods are well suited for decision making in drug development and therapeutics due to their formal inclusion of prior information and specification of inferences in terms…

Throw open the basement hatch (virtually) and join Metrum Research Group for an open-learning approach to open-science.

After a brief introduction to mrgsolve (https://mrgsolve.github.io), we will discuss concepts and applications for using the package in R to simulate from pharmacokinetic (PK) and physiologically-based PK (PBPK) models, estimate parameters given a model and data, and visualize simulation results with a Shiny app. We will establish a basic framework for running optimization in R and work hands-on examples using different optimizers, including local and global search algorithms. Building on this framework, we will also illustrate related workflows including global…