Simulation Concepts and their Application to Model‐Informed Drug Development

Workshop presented 24-25 October 2019 at American Conference on Pharmacometrics in Orlando, FL by instructors Michael Heathman, M.S., Kyle Baron, Pharm.D., Ph.D., and Marc Gastonguay, Ph.D.

This one-and-a-half-day hands-on workshop provided participants with a foundation for applying simulation to decision-making in the drug development process. The workshop began with a discussion of how to translate key questions into quantitative decision criteria, suitable to be addressed through simulation. This was followed by an introduction to mrgsolve, an open-source platform for simulation in R (https://mrgsolve.github.io), and a discussion of fundamental simulation concepts, such as how to implement uncertainty and variability to produce appropriate simulation output. Finally, the workshop wrapped up with hands-on case studies in mrgsolve, allowing the students to implement what they’ve learned.

Material from the workshop can be found here.