Simulation Concepts and their Application to Model‐Informed Drug Development

Workshop presented 24-25 October 2019 at American Conference on Pharmacometrics in Orlando, FL by instructors Michael Heathman, M.S., Kyle Baron, Pharm.D., Ph.D., and Marc Gastonguay, Ph.D.

This one-and-a-half-day hands-on workshop provided participants with a foundation for applying simulation to decision-making in the drug development process. The workshop began with a discussion of how to translate key questions into quantitative decision criteria, suitable to be addressed through simulation. This was followed by an introduction to mrgsolve, an open-source platform for simulation in R (, and a discussion of fundamental simulation concepts, such as how to implement uncertainty and variability to produce appropriate simulation output. Finally, the workshop wrapped up with hands-on case studies in mrgsolve, allowing the students to implement what they’ve learned.

Material from the workshop can be found here.

Thank you for your interest.

Please fill out the form below to download the course materials. Or you can download here.