PBPK and QSP model implementation and utilization in R

In this tutorial session, we will review case studies in PBPK and QSP modeling and simulation using mrgsolve in R. mrgsolve (https://mrgsolve.github.io) is a free, open-source modeling and simulation platform to support ODE-based model development in R. This content was presented in collaboration with Metrum Research Group, University of Florida Center for Pharmacometrics and Systems Pharmacology, and the ISoP Student Leadership Committee in March 2018.


Course materials can be found at:

1. mrgsolve overview (brief tutorial)
2. PBPK model characterizing drug-drug interactions between HMG-CoA reductase inhibitors and cyclosporine (Yoshikado et al. 2016; PMID 27170342)
a. Sensitivity analyses
b. Parameter estimation
3. Evaluation of combination chemotherapy regimens using a QSP model for MAP kinase signaling in colorectal cancer (Kirouac et al. 2017; PMID 28649441)
a. Create complicated input data sets
b. Options for parallelizing simulations
4. Discussion

Presented by Metrum Research Group
Instructors: Kyle Baron Pharm.D., Ph.D., Matthew Riggs, Ph.D.

Materials Provided by Sponsor: Course slides, data and code for all examples.

Requirements for Attendees: Knowledge and experience in population PKPD modeling and a laptop with WiFi internet capability.