Publications
The following publications and poster presentations are available for viewing in pdf.
2008
- Fisher J, Gastonguay MR, Knebel W, Gibiansky L, Wire MB. Population Pharmacokinetic Modeling of Fosamprenavir in Pediatric HIV- Infected Patients. American Conference on Pharmacometrics, 2008.
- Gillespie WR, Gastonguay MR, Knebel W, Georgalis G. Open Source Software Tools for Parallel Computation of Multiple MCMC Chains with WinBUGS. American Conference on Pharmacometrics, 2008.
- Knebel W, Bergsma T, Fisher J, Georgalis G, Gibiansky L, Gillespie WR, Riggs MM, and Gastonguay MR. Facilitating the Pharmacometrics Work-Flow with the MItools R Package. American Conference on Pharmacometrics, 2008.
- Riggs MM, Bergsma TT, Gillespie WR, Gastonguay MR, Sprenger KJ. Use of Rpad, an Open-Source, Interactive, Web-Based Analysis Program, for Visualization During Model-Based Drug Development of Adipiplon, a GABAA Receptor Partial Agonist Under Investigation for the Treatment of Insomnia. American Conference on Pharmacometrics, 2008.
2007
- Gillespie WR, Gastonguay MR, and Knebel W. Bayesian Approaches to Mixed Effects Models for Ordered Categorical Data. 2007 AAPS Annual Meeting & Exposition: Population PK/PD Analysis and Clinical Trial Simulations Session, 2007.
- Faessel HM, Rawa P, Gastonguay MR, Rohrbacher KD, Tenfeldt TG. Population Pharmacokinetic Analysis of Varenicline in Adult Smokers. Clin Pharmacol Ther 2007; 81(S1), Abstract PI-26: S20-21.
- Rawa P, Faessel H, Gastonguay MR, Tensfeldt TG, Reeves K. Quantitative Assessment of Exposure-Response Relationships for the Efficacy and Tolerability of Varenicline for Smoking Cessation. Clin Pharmacol Ther 2007; 81(S1), Abstract PII-73: S72.
2006
- Agoram B, Heatherington AC, Gastonguay MR. Development and evaluation of a population pharmacokinetic-pharmacodynamic model of darbepoetin alfa in patients with nonmyeloid malignancies undergoing multicycle chemotherapy. AAPS Journal. 8(3), 2006.
- Riggs M. Exposure-response (PK-PD) applied to model-based drug development: A case study
of Drug X. FDA/Industry Statistics Workshop (2006) Parallel Session 14: Case Studies in Modeling and Simulation, Abstract.
- Gastonguay MR, Gibiansky L. Acknowledging and Incorporating Uncertainty in Model-Based Inferences. ECPAG Conference (2006) Workshop Poster Session, Abstract.
- Gibiansky L and MR Gastonguay. R/NONMEM Toolbox for Simulation from Posterior Parameter (Uncertainty) Distributions. L. Gibiansky and M.R. Gastonguay. PAGE ( 2006) Abstract 958.
- Gibiansky E, Gibiansky L. Model-based drug development: Optimization of AQUAVAN® injection dosing for minimal-to-moderate sedation. PAGE 15 (2006) Abstract 959.
- Mondick JT, Gibiansky L, Gastonguay MR, Veal GJ, Barrett JS. Acknowledging parameter uncertainty in the simulation-based design of an actinomycin-D pharmacokinetic study in pediatric patients with Wilms’ Tumor or rhabdomyosarcoma. PAGE 15 (2006) Abstract 938.
- Gastonguay MR, Gibiansky L. Acknowledging Parameter Uncertainty by Simulating from Posterior Distributions with NONMEM and R. MUFPADA Annual Meeting (2006) Abstract.
2005
- Gatonguay MR, El-Tahtawy A. Modeling and Simulation Guided
Design of a Pediatric Population Pharmacokinetic Trial for
Hydromorphone. The AAPS Journal. Vol. 7, No. S2, Abstract W5318, 2005.
- Gastonguay MR and El-Tahtawy A. Effect of NONMEM Minimization Status
and Number of Replicates on Bootstrap Parameter Distributions for
Population Pharmacokinetic Models: A Case Study.
Clinical Pharmacology
and Therapeutics; 77(2), Abstract P2, 2005.
- Gibiansky E, Gibiansky L, Enriquez J. Population Pharmacokinetic Model of Sedative Doses of GPI 15715 and Propofol Liberated from GPI 15715. Clinical Pharmacology and Therapeutics; 77(2), Abstract PI-154, 2005.
- Gastonguay MR, Venitz J, Steffen R, Hackman J. Population Pharmacokinetic–Pharmacodynamic Modeling of Efaproxiral in Cancer Patients Receiving Radiation Therapy. Clinical Pharmacology and
Therapeutics; 77(2), Abstract P89, 2005.
- Knebel B, Bergsma T, Gibiansky L, Hane JT, Gastonguay MR. NMQual: A Tool to Automate Installation and Facilitate Qualification of NONMEM. PAGE Annual Meeting: Abstracts, 2005.
2004
- Gastonguay MR and Hane JT. The Importance of the Simulation Expectation as a Goodness of Fit Diagnostic for Categorical Population Pharmacodynamic Models. The AAPS Journal; 6(S1), Abstract W4355, 2004.
- Gastonguay MR and Bies R. Estimation and Prediction of Chaotic Pharmacodynamic Systems Using Nonlinear Mixed-Effects Models: The Butterfly
Effect. The AAPS Journal; 6(S1), Abstract W4353, 2004.
- Gastonguay MR. A Full Model Estimation Approach for Covariate Effects: Inference Based on Clinical Importance and Estimation Precision. The AAPS Journal; 6(S1), Abstract W4354, 2004.
- Gibiansky L. NONMEM Non-Influential Correlated ETAs Bug and How to Fix It. AAPS Annual Meeting: PPDM Poster-Podium Session, 2004.
